I know very few patents who don't feel isolated at least part of the time. Staying at home with little kids can be gruelingly lonely, and working out of the house can be just as lonely unless you really connect with coworkers. And even if you do have connections at work, you can still feel isolated in parenting when you're at home.
I advocate pushing yourself to get out and find friends in your local community, but sometimes that just doesn't work out for a variety of reasons.
So I guess my question for everyone reading this is: How do you manage the isolation? I know that I would not be able to make it without my friends in the computer, but there are other strategies we must be using to get through the years of raising little children. Let's share.